Protective Effects of Bile Acids Against Hepatic Lipid Accumulation in Hybrid Grouper Fed a High-Lipid Diet

• DOI: 10.3389/fnut.2022.813249
• Publication Date: 2022-01-25T05:15:31Z
• Authors: Jia Xu; Xiaoyue Li; Xinzhou Yao; Shiwei Xie; Shuyan Chi; Shuang Zhang; Junming Cao; Beiping Tan
• Keywords: Lipid Accumulation; Lipid Profile

Bile acids (BAs) usually display growth-promoting and lipid-lowering properties when supplemented to the diet. The effects of a high-lipid diet (HD) BAs supplementation on growth performance lipid deposition hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) was evaluated in this study. Compared control (CD), HD did not significantly affect fish performance, but it promoted deposition, as revealed by higher crude content whole body, muscle, liver. Among with taurocholic acid (BD) groups, compared HD, fed dietary at 900 mg kg-1 exhibited best lowest hepatic deposition. In most BD total cholesterol, low-density lipoprotein triglycerides serum, well cholesterol liver, were decreased, whereas high-density serum increased. addition, strongly influenced pathways between control, B3D groups fatty biosynthesis, insulin signaling pathway, AMPK pathway. improvement metabolism induced may be attributed decreased expression lipogenesis genes proteins (enzymes), increased lipolysis. conclusion, reduced accumulation, improved enhancing lipolysis, inhibiting lipogenesis, regulating associated transcriptional factors grouper.