An inverse causal association between genetically predicted vitamin D and chronic obstructive pulmonary disease risk

• DOI: 10.3389/fnut.2023.1111950
• Publication Date: 2023-03-15T05:30:20Z
• Authors: Kening Lu; Jiang-Shan Tan; Tian-Qi Li; Jiaqin Yuan; Han Wang; Wenting Wang
• Keywords: Association (psychology)

Observational studies have reported that levels of vitamin D were associated with the incidence chronic obstructive pulmonary disease (COPD), but relationship between them may been confounded in previous studies. In this study, we aimed to determine 25-hydroxyvitamin (25OHD) and risk COPD by two-sample Mendelian randomization (MR) analysis. Summary statistics for 25OHD study obtained from EBI (n = 496,946) consortium Finn 187,754) consortium. MR was adopted explore effect genetically predicted on COPD. Based three assumptions analysis, inverse variance weighting used as main To make our results more robust reliable, Egger's intercept test, Cochran's Q funnel plot, "leave-one-out" sensitivity analysis assess potential pleiotropy heterogeneity study. Then, colocalization Steiger approaches estimate possible directions estimates them. Finally, analyzed causal associations four core genes (DHCR7, GC, CYP2R1, CYP24A1) or Our showed each 1 standard deviation (SD) increase level a 57.2% lower relative [odds ratio (OR): 0.428, 95% Cl: 0.279-0.657, p 1.041 × 10-4], above association also verified maximum likelihood (OR: 0.427, 0.277-0.657, 1.084 10-4), MR-Egger 0.271, CI: 0.176-0.416, 2.466 MR-PRESSO 0.281-0.652, 1.421 10-4) MR-RAPS 0.457, 0.293-0.712, 5.450 10-4). Furthermore, analyses (rs3829251, PP.H4 0.99) ("TRUE") reverse Besides, similar except CYP24A1. findings provide evidence risk. Taking measures supplement help reduce