Predictors for Fear of Cancer Recurrence in Breast Cancer Patients Referred to Radiation Therapy During the COVID-19 Pandemic: A Multi-Center Cross-Section Survey

• DOI: 10.3389/fonc.2021.650766
• Publication Date: 2021-07-26T14:41:17Z
• Authors: Jinrong Xie; Weixiang Qi; Lu Cao; Yuting Tan; Jin Huang; Xiaodong Gu; Bingguang Chen; Peipei Shen; Yutian Zhao; Ying Zhang; Qingwen Zhao; Hecheng Huang; Yubin Wang; Haicheng Fang; Zhenjun Jin; Hui Li; Xuehong Zhao; Xiaofang Qian; Feifei Xu; Dan Ou; Shubei Wang; Cheng Xu; Min Li; Zefei Jiang; Yu Wang; Xiaobo Huang; Jiayi Chen
• Keywords: 03 medical and health sciences; breast cancer; fear of cancer recurrence (FCR); 0302 clinical medicine; quality of life; Oncology; delayed radiotherapy initiation; COVID-19; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282; cross-section study; 3. Good health

ObjectiveThe outbreak of COVID-19 pandemic has greatly impacted on radiotherapy (RT) strategy for breast cancer patients, which might lead to increased distressing psychological symptoms. We performed a multi-center cross-section survey to investigate prevalence of fear of cancer recurrence (FCR) and predictors for FCR in patients referred to RT during pandemic.Methods542 patients were consecutively enrolled from three regions in China including Yangtze Delta River Region, Guangdong and Shanxi province. Patients’ characteristics were collected using an information sheet, Fear of progression questionnaire-short form, Hospital Anxiety/Depression Scale and EORTC QLQ-C30. The hierarchical multiple regression models were performed.Results488 patients with complete data were eligible. The RT strategy was affected in 265 (54.3%) patients, including 143 with delayed RT initiation, 66 believing to have delayed RT initiation but actually not, 24 with RT interruptions, 19 shifting to local hospitals for RT and the remaining 13 influenced on both RT schedule and hospital level. The model explained 59.7% of observed variances in FCR (p<0.001) and showed that influence of RT strategy had significantly impacted on FCR (△R2 = 0.01, △F=2.966, p=0.019). Hospitals in Shanxi province (β=-0.117, p=0.001), emotional function (β=-0.19, p<0.001), social function (β=-0.111, p=0.006), anxiety (β=0.434, p<0.001) and RT interruption (β=0.071, p=0.035) were independent predictors.ConclusionsRT strategy for breast cancer patients was greatly influenced during pandemic. RT interruption is an independent predictor for high FCR. Our findings emphasize the necessity to ensure continuum of RT, and efforts should be taken to alleviate FCR through psychological interventions.