Baseline Serum C-Reactive Protein and Plasma Fibrinogen-Based Score in the Prediction of Survival in Glioblastoma

• DOI: 10.3389/fonc.2021.653614
• Publication Date: 2021-03-04T09:02:20Z
• Authors: Johannes Wach; Stefanos Apallas; Matthias Schneider; Agi Güresir; Patrick Schuss; Ulrich Herrlinger; Hartmut Vatter; Erdem Güresir
• Keywords: Univariate analysis; Univariate

Objective: The present study investigates a score based on baseline C-reactive protein (CRP) and fibrinogen values (FC score) in 173 consecutive glioblastoma (GBM) patients. Methods: optimal cut-off value for CRP was defined as 3.5 g/dl 3.0 mg/L, respectively, according to previous reports. Patients with elevated were classified of 2, those an elevation only one these parameters allocated 1, without any abnormalities assigned 0. Results: No significant differences age, gender, tumor area, molecular pathology, physical status, or extent resection identified among the three groups by this score. Univariate survival analysis demonstrated that high FC (≥1) is significantly associated shortened overall (OS) (HR: 1.52, 95% CI: 1.05–2.20, p = 0.027). A multivariate Cox regression considering age (>65/≤65), (GTR/STR), MGMT promoter status (hypermethylated/non-hypermethylated), (0/≥1) confirmed independent predictor OS 1.71, 1.16–2.51, 0.006). Conclusions: thus serves GBM. Further investigations role inflammation prediction prognosis are needed.