Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients

• DOI: 10.3389/fonc.2021.658004
• Publication Date: 2021-05-13T06:21:54Z
• Authors: Elise Konradsson; Maja L. Arendt; Kristine Bastholm...; Betina Børresen; Anders E. Hansen; Sven Bäck; Annemarie T. Kris...; Per Munck af Rose...; Crister Ceberg; Kristoffer Petersson
• Keywords: External beam radiotherapy; Erythema

FLASH radiotherapy has emerged as a treatment technique with great potential to increase the differential effect between normal tissue toxicity and tumor response compared conventional radiotherapy. To evaluate feasibility of in relevant clinical setting, we have commenced safety study canine cancer patients spontaneous superficial solid tumors or microscopic residual disease, using electron beam our modified linear accelerator. The setup for was established short applicator nominal source-to-surface distance 70 cm custom-made Cerrobend blocks collimation. characterized by measuring dose profiles depth curves various field sizes. Ten were included this initial study; seven nine three disease. administered ranged from 15 35 Gy. ensure correct delivery prescribed dose, film measurements performed prior during treatment, Farmer-type ion-chamber used monitoring. Treatments found be feasible, partial response, complete stable disease recorded 11/13 irradiated tumors. Adverse events observed at follow-up ranging 3-6 months mild consisted local alopecia, leukotricia, dry desquamation, erythema swelling. One patient receiving Gy nasal planum, had grade 3 skin adverse event. Dosimetric procedures, an efficient clincal workflow established. experience will basis veterinary phase I/II trial more specific inclusion selection, subsequently human trials.