Development and Validation of a Prognostic Nomogram for Hypopharyngeal Carcinoma

• DOI: 10.3389/fonc.2021.696952
• Publication Date: 2021-06-21T08:49:56Z
• Authors: Shu Tian; Qin Li; Ruichen Li; Xinyu Chen; Zhonghua Tao; Hongli Gong; Xiaoshen Wang; Xichun Hu
• Keywords: Nomogram; Interquartile range; Concordance; T-stage

Hypopharyngeal squamous-cell carcinoma (HSCC) is a relatively rare head and neck cancer, with great variation in patient outcomes. This study aimed to develop prognostic nomogram for patients HSCC. From the Surveillance, Epidemiology, End Results (SEER) database, we retrieved clinical data of 2198 diagnosed HSCC between 2010 2016. The were randomly assigned at 4:1 ratio training set or validation set. An external was performed by 233 locally advanced treated our center. A Cox proportional hazards regression model used assess relationship each variable overall survival (OS). multivariate analysis performed, results nomogram. calibration curve concordance index (C-index) evaluate accuracy With median follow-up time 41 months (interquartile range: 20 61), OS entire cohort SEER database 24 months. 3-year 5-year rates 41.3% 32.5%, respectively. showed that age, marital status, race, T stage, N M TNM local treatment, chemotherapy correlated OS. superior C-index over stage (training set: 0.718 vs 0.627; 0.708 0.598; 0.709 0.597), high level predicted actual provides accurate applicable prediction outcome