Chemical Synthesis of the PAX Protein Inhibitor EG1 and Its Ability to Slow the Growth of Human Colorectal Carcinoma Cells

• DOI: 10.3389/fonc.2021.709540
• Publication Date: 2021-10-13T18:08:34Z
• Authors: Lorissa McDougall; Jui Thiang Brian ...; Jake Ward; Joel D. A. Tyndall; Adele G. Woolley; Sunali Mehta; Cherie Stayner; David S. Larsen; Michael R. Eccles
• Keywords: Transcription; Epigenomics

Colorectal cancer is primarily a disease of the developed world. The incidence rate has continued to increase over time, reflecting both demographic and lifestyle changes, which have resulted in genomic epigenomic modifications. Many epigenetic modifications occur genes known be closely associated with embryonic development cellular growth. In particular, paired box (PAX) transcription factors are crucial for correct tissue during embryogenesis due their role regulating involved proliferation maintenance. number cancers, including colorectal cancer, PAX aberrantly expressed, driving thus increased tumour Here we synthesized used small molecule inhibitor, EG1, inhibit HCT116 cell cultures reduced after three days treatment. These results highlight as playing an important cells, suggesting there may potential therapeutic inhibition limiting