Identification of U937JAK3-M511I Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor

• DOI: 10.3389/fonc.2021.807200
• Publication Date: 2022-01-17T05:17:50Z
• Authors: Hongfei Si; Jie Wang; Rui He; Xiuwen Yu; Shan Li; Jing Huang; Jie Li; Xia Tang; Xiaojuan Song; Zhengchao Tu; Zhang Zhang; Ke Ding
• Keywords: U937 cell; Janus kinase 3

Mutated JAK3 has been considered a promising target for cancer therapy. Activating mutations of are observed in 3.9%-10% acute myeloid leukemia (AML) patients, but it is unclear whether AML cells sensitive to inhibitors, and no disease-related human cell model reported. We have identified U937 as the first line expressing JAK3M511I activated mutation confirmed that inhibitors sensitively suppress proliferation cells.