MARCH1 as a novel immune-related prognostic biomarker that shapes an inflamed tumor microenvironment in lung adenocarcinoma

• DOI: 10.3389/fonc.2022.1008753
• Publication Date: 2022-10-13T06:40:57Z
• Authors: Zhiyong Xu; Jun Liu; Zichuan Liu; Haibo Zhang
• Keywords: Immune checkpoint

E3 ubiquitin ligases (E3s), the second most common cancer-related functional protein family, play vital roles in multiple tumors. However, their importance prognosis and immunotherapy of lung adenocarcinoma (LUAD) is not clear. First, utilizing data from The Cancer Genome Atlas (TCGA), we comprehensively assessed expression profile immunological association 13 E3s LUAD patients. Consequently, MARCH1 was considered a candidate for further study. Second, several algorithms were applied to assess correlation between characteristics tumor microenvironment. Third, an immune risk score (IRS) developed predict prognosis. Finally, relationship pan-cancer also estimated. We found that disordered LUAD. Among them, positively correlated with characteristics, indicating designed inflamed TME Coincidently, low had poor sensitive checkpoint blockers. In addition, IRS could accurately pan-cancer, characteristics. conclusion, be novel promising biomarker status effectiveness