Identification of Differentially Expressed Hub Genes Associated With Immune Cell Recruitment in Claudin-Low Breast Cancer

• DOI: 10.3389/fonc.2022.848206
• Publication Date: 2022-03-11T10:32:49Z
• Authors: Yange Wang; He Shi; Yulu Zhang; Qian Zeng; Tingmei Chen; Chengsen Chai
• Keywords: CCL5; Claudin

Breast cancer (BCa) is the most common malignancy in women and claudin-low breast (CL-BCa) a newly identified BCa subtype characterized by low expression of claudin 3&4&7. However, hub genes associated with recruitment immune cells into CL-BCa were rarely described. This study aimed at exploring differentially expressed tumor-infiltrating multi-approach bioinformatics analysis. The top 200 screened METABRIC dataset; PPI network was constructed using STRING Cytoscape; analyzed TIMER 2.0; correlation feature cytokines claudins on survival examined TCGA datasets. Consequently, we found that fraction cells, especially CD8+T macrophages, increased CL-BCa. Differentially (CCL5, CCL19, CXCL9 CXCL10) related to overall survival, their levels also both tumor tissues patients IHC typical cell lines qPCR. Moreover, these (CLDN8, CLDN11 CLDN19) showed worse survival. sheds light molecular features microenvironments contributes identification prognosis biomarkers for patients.