Survival of Patients With UrAC and Primary BAC and Urothelial Carcinoma With Glandular Differentiation

• DOI: 10.3389/fonc.2022.860133
• Publication Date: 2022-05-12T05:54:27Z
• Authors: Tao Wang; Zheng Lv; Huayi Feng; Jinlong Li; Bo Cui; Yang Yang; Xing Huang; Xiangyi Zhang; Xintao Li; Xin Ma
• Keywords: Primary (astronomy)

Purpose To investigate the significance of demographic and pathological characteristics on survival outcomes urachal adenocarcinoma (UrAC), primary bladder (BAC) urothelial carcinoma with glandular differentiation (UCGD) in China. Materials Methods We retrospectively analyzed cases non-distant metastases (≤ T4M0). Of 106 patients, 30 (28.3%), 40 (37.7%), 36 (34.0%) met criteria for UrAC, BAC, UCGD, respectively. Data patient demographics, tumor pathology, were collected. The median follow-up was months. Survival using multivariate Cox regression. Results Patients UrAC younger (51.87 ± 15.25 years) than those BAC (60.50 12.56 UCGD (63.83 11.60 ( P <0.001). most likely to be stage T3–4 (70.0% vs . 40.0% 44.4%; <0.001), while group had a higher rate poor groups (57.4% 18.5% 24.1%; Kaplan–Meier curves showed that overall (OS), progression-free (PFS), disease-specific (DSS) poorer both (P=0.0046,P<0.0001,P=0.0077 respectively). Regarding patients mucinous tended have better OS PFS other histological types (P<0.005,P=0.0245). Multivariate regression analysis revealed type =0.002), T =0.034), age-adjusted Charlson Comorbidity Index (aCCI) scores =0.005) predicted postoperative DSS patients. For PFS, =0.011), grade =0.000), aCCI =0.002) predictive. Conclusion Among prognosis poorest BAC. Attempts should made diagnose these aggressive tumors early, since whom are detected early appear survive longer.