Amide proton transfer weighted imaging combined with dynamic contrast-enhanced MRI in predicting lymphovascular space invasion and deep stromal invasion of IB1-IIA1 cervical cancer

• DOI: 10.3389/fonc.2022.916846
• Publication Date: 2022-09-12T08:00:41Z
• Authors: Qingling Song; Shifeng Tian; Changjun Ma; Xing Meng; Lihua Chen; Nan Wang; Liangjie Lin; Jiazheng Wang; Qingwei Song; Ailian Liu
• Keywords: Dynamic Contrast-Enhanced MRI; Dynamic contrast; Lymphovascular invasion

To investigate the value of amide proton transfer weighted (APTw) imaging combined with dynamic contrast-enhanced magnetic resonance (DCE-MRI) in predicting intermediate-risk factors deep stromal invasion (DSI) and lymphovascular vascular space (LVSI) cervical cancer.Seventy patients cancer who underwent MRI before operation from July 2019 to February 2022 were retrospectively included this study. Clinical information including age, histologic subtype etc. recorded for patients. ATPw parameter APTmean DCE-MRI parameters Ktrans, Kep Ve measured analyzed. The independent-sample t-test, Mann-Whitney U test, or Chi-square test was used compare differences between DSI/LVSI positive negative groups. Logistic analysis develop a predictive model. receiver operating characteristic curve performance. ANOVA Kruskal-Wallis consecutive among multiple groups.Ktrans SCC-Ag independent DSI; Ktrans+SCC-Ag had highest AUC 0.819 sensitivity specificity 71.74% 91.67%, respectively. Ktrans LVSI; APTmean+Ktrans 0.874 92.86% 75.00%, could discriminate coexistence DSI LVSI presence single one, no risk factor presence.The combination APTw is valuable cancer.