Prognostic value of normal sodium levels in patients with metastatic renal cell carcinoma receiving tyrosine kinase inhibitors

• DOI: 10.3389/fonc.2022.918413
• Publication Date: 2022-08-16T05:00:38Z
• Authors: Giandomenico Rovi...; Martina Catalano; Ugo De Giorgi; Marco Maruzzo; Sebastiano Buti; Elisabetta Gambale; Giuseppe Procopio; Carlotta Ottanelli; Enrico Caliman; Luca Isella; Pierangela Sepe; Nicole Brighi; Matteo Santoni; Luca Galli; Raffaele Conca; Laura Doni; Lorenzo Antonuzzo
• Keywords: Log-rank test; Univariate analysis

Although serum sodium concentration, particularly hyponatremia, has been shown to be a prognostic marker of survival in metastatic renal cell carcinoma (mRCC), the impact normal levels not investigated. Herein, we investigate influence normonatremia mRCC patients treated with tyrosine kinase inhibitors (TKIs).For this retrospective study, clinical and biochemical data first-line TKIs for were available from seven Italian cancer centers. We collected natremia at baseline first evaluation after treatment excluding outside range (<135 or >145 mEq/L). The remaining subdivided into two groups according median value: <140 mEq/L (n = 132) ≥140 185). Subsequently, analyzed on response rate (RR), disease control (DCR), progression-free (PFS), overall (OS). PFS OS estimated through Kaplan-Meier method, differences between examined by log-rank test. Univariate multivariate Cox regression analyses applied evaluate factors OS.Of 368 patients, 317 included analysis, 73.1% men, age was 67 years (range 36-89). When comparing 185) 132), 15 vs. 10 months (p < 0.01) 63 36 months, respectively 0.02). On evaluation, had longer (15 p (70 32 than mEq/L. Moreover, outcomes showed significant improvement compared both evaluation: 19 11 70 0.01), respectively.To best our knowledge, is study mRCC. found that assessment are independently associated worse setting.