In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO

• DOI: 10.3389/fonc.2022.929949
• Publication Date: 2022-09-26T13:28:32Z
• Authors: Martina Moglioni; Aafke Christine K...; Guido Baroni; Giuseppe Battistoni; Nicola Belcari; Andrea Berti; Pietro Carra; Piergiorgio Cerello; Mario Ciocca; Angelica De Gregorio; Micol De Simoni; Damiano Del Sarto; Marco Donetti; Yunsheng Dong; Alessia Embriaco; Maria Evelina Fan...; Veronica Ferrero; Elisa Fiorina; Marta Fischetti; Gaia Franciosini; Giuseppe Giraudo; Francesco Laruina; Davide Maestri; Marco Magi; Giuseppe Magro; Etesam Malekzadeh; Michela Marafini; Ilaria Mattei; Enrico Mazzoni; Paolo Mereu; Alfredo Mirandola; Matteo Morrocchi; Silvia Muraro; Ester Orlandi; Vincenzo Patera; Francesco Pennazio; Marco Pullia; Alessandra Retico; Angelo Rivetti; Manuel Dionisio D...; Valeria Rosso; Alessio Sarti; Angelo Schiavi; Adalberto Sciubba; Giancarlo Sportelli; Sara Tampellini; Marco Toppi; Giacomo Traini; Antonio Trigilio; Serena Marta Valle; Francesca Valvo; Barbara Vischioni; Viviana Vitolo; Richard Wheadon; Maria Giuseppina ...
• Keywords: Particle Therapy

Morphological changes that may arise through a treatment course are probably one of the most significant sources range uncertainty in proton therapy. Non-invasive in-vivo monitoring is useful to increase quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs and carbon therapy treatments at National Center Oncological Hadrontherapy (CNAO). It currently clinical trial (ID: NCT03662373) has acquired PET data during various patients. In this work we analyze (IB-PET) eight patients treated with CNAO. goal analysis twofold. First, assess level experimental fluctuations inter-fractional differences (sensitivity) system by studying without morphological changes. Second, use obtained results see whether can observe anomalously large variations where have occurred. sensitivity IB-PET was quantified as standard deviation difference distributions observed for six did not show Inter-fractional respect reference distribution were estimated using Most-Likely-Shift (MLS) method. To establish efficacy method, made comparison Beam's Eye View (BEV) For showing no control CT average variation found be 2.5 mm MLS method 2.3 BEV On other hand, some small anatomical occurred, larger values. these evaluated anomalous compared them CT. We identified regions mostly agreement seen scan.