Trends in metabolic signaling pathways of tumor drug resistance: A scientometric analysis

• DOI: 10.3389/fonc.2022.981406
• Publication Date: 2022-10-25T07:46:24Z
• Authors: Ruiqi Jiang; Mingnan Cao; Shenghui Mei; Shanshan Guo; Wei Zhang; Nan Ji; Zhigang Zhao
• Keywords: 0301 basic medicine; tumor; 03 medical and health sciences; drug resistance; Oncology; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; scientometrics; metabolism; signaling pathways; RC254-282; 3. Good health

Cancer chemotherapy resistance is one of the most critical obstacles in cancer therapy. Since Warburg O first observed alterations metabolism 1950s, people gradually found tumor pathways play a fundamental role regulating response to chemotherapeutic drugs, and attempts targeting energetics have shown promising preclinical outcomes recent years. This study aimed summarize knowledge structure identify emerging trends potential hotspots metabolic signaling drug research.Publications related published from 1992 2022 were retrieved Web Science Core Collection database. The document type was set articles or reviews with language restriction English. Two different scientometric software including Citespace VOS viewer used conduct this analysis.A total 2,537 publications 1,704 833 final analysis. USA made contributions field. leading institution University Texas MD Anderson Center. Avan A productive author, Hanahan D key researcher co-citations, but there no leader field yet. Cancers influential academic journal, Oncology popular research Based on keywords occurrence analysis, these selected could be roughly divided into five main topics: cluster 1 (study cell apoptosis pathway); 2 mechanisms types); 3 stem cells); 4 oxidative stress inflammation pathways); 5 autophagy). burst detection identified several as new hotspots, "tumor microenvironment," "invasion," "target".Tumor reprogramming advancing rapidly. serves starting point, providing thorough overview, development landscape, future opportunities