Specific gene expression signatures of low grade meningiomas

• DOI: 10.3389/fonc.2023.1126550
• Publication Date: 2023-03-01T07:26:22Z
• Authors: Erdyni N. Tsitsikov; Sanaa Hameed; Sherwin A. Tavakol; Tressie M. Stephens; Alla V. Tsytsykova; Lori Garman; Wenya Linda Bi; Ian F. Dunn
• Keywords: Oncology; NF2; gene expression; CNS tumors; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; transcriptome profiling; meningioma; RC254-282; 3. Good health; TRAF7

Meningiomas are the most common primary central nervous system (CNS) tumors in adults, representing approximately one-third of all adult CNS tumors. Although several recent publications have proposed alternative grading systems meningiomas that incorporate genomic and/or epigenomic data to better predict meningioma recurrence and progression-free survival, our understanding driving forces development is still limited.To define gene expression signatures subtypes understand cellular processes signaling pathways specific for each tumor genotype.We used RNA sequencing (RNA-seq) determine whole transcriptome profiles twenty with alterations including NF2 inactivation, loss chr1p, missense mutations TRAF7, AKT1 KLF4.The analysis revealed inactivation expressed higher levels BCL2 GLI1 compared harboring TRAF7 mutations. Moreover, were subdivided into two distinct groups based on additional chr1p. intact chr1p characterized by high suppressor PTCH2 loss. Taken together GLI1, these results suggest activation Sonic Hedgehog pathway may contribute development. In contrast, transcription factor FOXD3 its antisense FOXD3-AS1. Examination demonstrated regulates a number biomechanically responsive genes (KRT6a, KRT16, IL1RL1, AQP3 among others). Interestingly, KLF4 PI3K/AKT pathway, suggesting overlapping between subtypes. addition, had carcinoembryonic antigen family members CEACAM6 CEACAM5.Each group displayed unique signature potentially implicated tumorigenesis. These findings will improve tumorigenesis prognosis.