Association of psychological distress, smoking and genetic risk with the incidence of lung cancer: a large prospective population-based cohort study

• DOI: 10.3389/fonc.2023.1133668
• Publication Date: 2023-07-14T02:06:03Z
• Authors: Jing Zhang; Yi Wang; Tingting Hua; Xiaoxia Wei; Xiangxiang Jiang; Mengmeng Ji; Zhimin Ma; Yanqian Huang; Hui Wang; Lingbin Du; Meng Zhu; Lin Xu; Weibing Wu; Hongxia Ma
• Keywords: Depression

Emerging evidence suggests a potential link between psychological distress (anxiety and depression) lung cancer risk, however, it is unclear whether other factors such as tobacco smoking genetic susceptibility modify the association.We included 405,892 UK Biobank participants free of at baseline. Psychological was measured using Patient Health Questionnaire-4 (PHQ-4). A polygenic risk score (PRS) calculated 18 cancer-associated loci. Multivariable Cox regression models were used to estimate hazard ratios (HRs) 95% confidence intervals (CIs).During median follow-up 7.13 years, 1754 cases documented. The higher associated with an increased (HRper 1-SD= 1.07, CI: 1.02-1.11) after adjustment for confounders. Mediation analysis revealed that 16.8% (95% 13.0%-20.6%) distress-lung association mediated by smoking. Compared never smokers no distress, heavy high had highest (HR=18.57, 14.51-23.76). Both multiplicative additive interactions observed in cancer. Furthermore, greatest relative increase among those (HR=1.87, 95%CI: 1.50-2.33), there significant interaction PRS distress.Our results indicate elevated incident cancer, relation modified susceptibility.