Association of modifiable lifestyle with colorectal cancer incidence and mortality according to metabolic status: prospective cohort study

• DOI: 10.3389/fonc.2023.1162221
• Publication Date: 2023-05-30T12:40:57Z
• Authors: Peng Xie; Siqing Wu; Zichong Kuo; Huidong Tian; Qiangsheng He; Yanfei Li; Ningning Mi; Linmin Hu; Haitong Zhao; Wenjing Li; Bin Xia; Jinqiu Yuan; Kehu Yang; Changhua Zhang; Yulong He
• Keywords: Metabolic equivalent

Metabolic syndrome has been linked to an increased risk of colorectal cancer (CRC) incidence and mortality, but whether adopting a healthy lifestyle could attenuate the CRC conferred by metabolic remains unclear. The aim study is investigate individual joint effects modifiable health status on mortality in UK population.This prospective included 328,236 individuals from Biobank. An overall was assessed at baseline categorized based presence or absence syndrome. We estimated association score (derived 4 behaviors: smoking, alcohol consumption, diet, physical activity into "favorable," "intermediate", "unfavorable") with stratified status.During median follow-up 12.5 years, 3,852 incidences 1,076 deaths were newly identified. incident its number abnormal factors decreased (P trend = 0.000). MetS associated greater (HR 1.24, 95% CI: 1.16 - 1.33) 1.08 1.41) when compared those without MetS. unfavorable 1.25, 1.15 1.36) 1.36, 1.59) across all status. Participants had higher 1.56, 1.38 1.76) 1.75, 1.40 2.20) than favorable MetS.This indicated that adherence substantially reduce burden regardless Behavioral changes should be encouraged for prevention even participants