Acute kidney injury and acute kidney disease in high-dose cisplatin-treated head and neck cancer

• DOI: 10.3389/fonc.2023.1173578
• Publication Date: 2023-06-09T05:15:43Z
• Authors: Francesco Trevisani; Federico Di Marco; Giulia Quattrini; Nicola Lepori; Matteo Floris; Davide Valsecchi; Leone Giordano; Italo Dell’Oca; Sara Cardellini; Alessandra Cinque; Aurora Mirabile
• Keywords: Concomitant; Cumulative dose

In locally advanced head and neck squamous cell carcinoma (LA-SCCHN) at least 200mg/m2 (standard dose 300 mg/m2) of cisplatin concomitant with radiotherapy represents the standard care, both in postoperative conservative settings. Nevertheless, high administration every 3 weeks is often replaced low weekly to avoid toxicities like kidney injury, though failing reach therapeutic dose. Our aim was investigate incidence renal impairment real-life setting, integrating adequate supportive therapy, explore Acute Kidney Injury (AKI) Disease (AKD), a recently described clinical syndrome that encompasses functional alterations lasting fewer than months.One hundred nine consecutive patients affected by LA-SCCHN treated cumulative dosage 200 mg/m2 were enrolled this prospective observational study.AKI reported 12.8% patients, 50% whom stage 1 (KDIGO criteria), while 25.7% cohort developed AKD. Patients baseline estimated Glomerular Filtration Rate (eGFR) < 90 ml/min showed higher AKD (36.2% vs 17.7%). Hypertension, eGFR, therapy Renin-angiotensin-aldosterone system inhibitors proved be significant factors associated AKI AKD.AKI are not rare complications high-dose cisplatin, but an appropriate prevention strategy accurate monitoring during treatment could lead reduction burden these conditions.