Case Report: Primary hepatic neuroendocrine tumor: two cases report with literature review

• DOI: 10.3389/fonc.2023.1225583
• Publication Date: 2023-08-04T11:51:05Z
• Authors: Yongsheng Tang; Xianyu Chen; Xu Lu; Zenan Yuan; Yang Yang; Chunhui Qiu; Hua Li
• Keywords: Liver tumor; Primary tumor

Primary hepatic neuroendocrine tumors (PHNETs) are rare malignant liver that present diagnostic challenges owing to their rarity and absence of specific clinical features. This study aimed investigate the characteristics this tumor enhance our understanding disease, improve accuracy, explore standardized treatment approaches.During physical examination, two elderly women, aged 64 74 years, were found have masses. 18F-FDG Positron Emission Tomography-Computed Tomography (18F-FDG PET-CT) Ga68-DOTATATE PET-CT scans both individuals revealed multiple masses initially suspected be tumors. Subsequent puncture pathology confirmed diagnosis Furthermore, in Case 1, was also detected by lung, suggesting a metastatic tumor, conjunction with immunohistochemistry imaging findings. Laboratory tests no significant abnormalities function or autoimmune disease indicators, there evidence viral hepatitis infection. However, partial hepatectomy not indicated for cases distant metastasis space-occupying lesions. Individualized approaches been developed such situations. A large portion underwent Transarterial Embolization (TAE), targeted combination chemotherapy endocrine therapy administered based on pathological results. During regular follow-ups 13 12 months, remained stable. The patients' quality life good, psychological well-being healthy. They led active lifestyles, demonstrated thorough its progression, actively cooperated during follow-up process.Our findings suggest serological, radiological, immunohistochemical examinations can aid PHNET. In addition, we determined TAE combined drug could an effective method controlling PHNET progression. Regular postoperative important monitoring prognosis progression status patients