Primary presentation and clinical course of pediatric and adolescent patients with differentiated thyroid carcinoma after radioiodine therapy

• DOI: 10.3389/fonc.2023.1237472
• Publication Date: 2023-10-03T04:34:15Z
• Authors: Caroline Burgard; Mathias Johannes ...; Andrei Todica; Julia Hornung; Freba Grawe; Isabell Pekrul; Petra Zimmermann; Christine Schmid-...; Roland Ladurner; Detlef Krenz; Arnold Trupka; Johanna Wagner; Peter Bartenstein; Christine Spitzweg; Vera Wenter
• Keywords: Presentation (obstetrics)

Differentiated thyroid carcinoma (DTC) in childhood and during adolescence is extremely rare. Pediatric DTC commonly presents with advanced disease at diagnosis including a high prevalence of cervical lymph node metastases pulmonary metastases. Studies children are limited. Therefore, we aimed to evaluate the initial presentation, effectiveness radioiodine therapy (RIT), long-term outcome prepubertal comparison pubertal/postpubertal patients.Eighty-five pediatric young patients aged 6.4 21.9 years histopathologically confirmed were retrospectively included. They all underwent total thyroidectomy followed by RIT. Initial presentation compared 1 year after RIT, follow-up, last visit follow-up.Prepubertal presented significantly higher T M stages. One 42/81 (52%) still evidence (ED). During follow-up median 7.9 years, less often complete remission (58% vs. 82% pubertal patients). At 19/80 (24%) had ED without statistical differences between two groups (42% 18% pubertal/postpubertal, p-value 0.06). None our died disease-related over observed period.Prepubertal more tumor stage presentation. they present ED. However, end study, did not observe statistically relevant patient outcomes groups.