Evaluation of single-fraction high dose FLASH radiotherapy in a cohort of canine oral cancer patients

• DOI: 10.3389/fonc.2023.1256760
• Publication Date: 2023-09-11T12:16:00Z
• Authors: Betina Børresen; Maja L. Arendt; Elise Konradsson; Kristine Bastholm...; Sven ÅJ. Bäck; Per Munck af Rose...; Crister Ceberg; Kristoffer Petersson
• Keywords: Fraction (chemistry)

Background FLASH radiotherapy (RT) is a novel method for delivering ionizing radiation, which has been shown in preclinical studies to have normal tissue sparing effect and maintain anticancer efficacy as compared conventional RT. Treatment of head neck tumors with RT commonly associated severe toxicity, hence the potentially makes it especially advantageous treating oral tumors. In this work, objective was study adverse effects dogs spontaneous treated Methods Privately-owned macroscopic malignant cavity were single fraction ≥30Gy electron subsequently followed 12 months. A modified linear accelerator used deliver Results Eleven enrolled prospective study. High grade common, if bone included treatment field. Four out six dogs, who had their field lived at least 5 months after RT, developed osteoradionecrosis 3-12 post treatment. The overall effective 8/11 complete clinical responses 3/11 partial responses. Conclusion This shows that single-fraction high dose generally mixed group tumors, but risk serious concern. It possible osteonecrosis can be mitigated through fractionation improved conformity, needs addressed before moving forward trials human cancer patients.