Immunogenic chemotherapy: great potential for improving response rates

• DOI: 10.3389/fonc.2023.1308681
• Publication Date: 2023-12-06T18:29:33Z
• Authors: Xiaojun Huang; Qinghuan Ren; Leixiang Yang; Di Cui; Chenyang Ma; Yueliang Zheng; Junjie Wu
• Keywords: Active immunotherapy

The activation of anti-tumor immunity is critical in treating cancers. Recent studies indicate that several chemotherapy agents can stimulate by inducing immunogenic cell death and durably eradicate tumors. This suggests holds great potential for improving response rates. However, practice has only had limited success long-term survival or cure cancers when used either alone combination with immunotherapy. We think this because the importance dose, schedule, tumor model dependence chemotherapy-activated under-appreciated. Here, we review immune modulation function representative propose a chemotherapy-induced long-lasting responses rely on synergetic interaction between killing cells immunity. comb through treatment schedules, identify needs dose schedule optimization therapy immunotherapy dosage responsiveness too low. further intrinsic factors affect optimal schedule. Lastly, biomarkers indicating to and/or treatments. A deep understanding how activates monitor its lead development more effective chemo-immunotherapy, thereby efficacy cancer treatment.