Modern cancer therapy: cryoablation meets immune checkpoint blockade

• DOI: 10.3389/fonc.2024.1323070
• Publication Date: 2024-02-07T23:47:37Z
• Authors: Qi Liu; Chunyang Zhang; Xuxin Chen; Zhihai Han
• Keywords: Cryoablation; Immune checkpoint

Cryoablation, as a minimally invasive technology for the treatment of tumors, destroys target tumors with lethal low temperatures. It simultaneously releases large number tumor-specific antigens, pro-inflammatory cytokines, and nucleoproteins, known “danger signals”, activating body’s innate adaptive immune responses. However, tumor cells can promote inactivation effector by reprogramming checkpoints, leading to insufficiency these antigens induce an response capable eradicating tumor. Immune checkpoint blockers rejuvenate exhausted T blocking checkpoints that programmed death cells, are therefore considered promising therapeutic strategy enhance effects cryoablation. In this review, we provide detailed explanation immunological mechanisms cryoablation articulate theoretical basis research progress cancer combined blockers. Preliminary data indicates exhibits good synergy has been proven be safe effective.