Predicting treatment failure in stage III colon cancer patients after radical surgery

• DOI: 10.3389/fonc.2024.1397468
• Publication Date: 2024-05-16T04:33:22Z
• Authors: Hao Zeng; Xuejing Zhong; Wenxin Liu; Baofeng Liang; Xueyi Xue; Nong Yu; Dongbo Xu; Xiaojie Wang; Shuangming Lin
• Keywords: Nomogram; Perineural invasion; Concordance; T-stage

Purpose The aim to assess treatment failure in patients with stage III colon cancer who underwent radical surgery and was analyzed using the nomogram. Methods Clinical factors survival outcomes for registered SEER database from 2018 2019 were analyzed, split into training testing cohorts (7:3 ratio). A total of 360 First Affiliated Hospital Longyan served as an external validation cohort. Independent predictors identified logistic regression analyses. nomograms evaluated by concordance index (C-index), calibration curves, area under curve (AUC), decision analysis (DCA) clinical impact curves (CIC) assessed utility versus TNM staging. Results study included 4,115 cancer. Multivariate age, tumor site, pT stage, pN chemotherapy, pretreatment CEA levels, number harvested lymph nodes, perineural invasion marital status independent risk failure. C-indices sets 0.853 0.841. Validation ROC confirmed stability reliability model. DCA showed that net effect histogram superior staging system, while CIC highlighted potentially large Conclusions developed Nomogram provides a powerful accurate tool clinicians after