Porphyromonas gingivalis, a bridge between oral health and immune evasion in gastric cancer

• DOI: 10.3389/fonc.2024.1403089
• Publication Date: 2024-05-14T04:49:56Z
• Authors: Matías Muñoz-Medel; Mauricio P. Pinto; Lauren Goralsky; Mónica Cáceres; Franz Villarroel-...; Patricio Manque; Andrés Pinto; Benjamin Garcia-Bloj; Tomas de Mayo; Juan A. Godoy; Marcelo Garrido; Ignacio N. Retamal
• Keywords: Evasion (ethics); Bridge (graph theory)

Porphyromonas gingivalis ( P. ) is a gram-negative oral pathogen associated with chronic periodontitis. Previous studies have linked poor health and periodontitis cancer. Severe cases of periodontal disease can result in advanced periodontitis, leading to tissue degradation, tooth loss, may also correlate higher gastric cancer (GC) risk. In fact, loss an elevated risk However, the clinical evidence for this association remains inconclusive. Periodontitis characterized by inflammation upregulation members Programmed Death 1/PD1 Ligand 1 (PD1/PDL1) axis that leads immunosuppressive state. Given immunosuppression are conditions facilitate progression carcinogenesis, we hypothesize and/or its virulence factors serve as mechanistic link between carcinogenesis/GC progression. We discuss potential impact ’ (gingipains, lipopolysaccharide (LPS), fimbriae) on response immune checkpoint inhibitors GC which part current standard care stage patients.