Dysregulation of saliva and fecal microbiota as novel biomarkers of colorectal cancer

• DOI: 10.3389/fonc.2024.1498328
• Publication Date: 2024-12-18T05:10:25Z
• Authors: Jiamei Rong; Xiaocui Chen; Zhangqin Li; Bona Li; Yang Sun; Yinglei Miao
• Keywords: Fecal bacteriotherapy

The aim of this study was to investigate the biomarkers salivary and fecal microbiota in Colorectal cancer (CRC). Initially, scrutinized microbial community composition disparities among groups. Utilizing Lasso analysis, it sifted through operational taxonomic units (OTUs) pinpoint distinctive features. Subsequently, by intersecting feature OTUs across groups, curated a set core-shared devised corresponding network. Concluding with functional enrichment research delved into divergent biological functions these communities within studied Analysis revealed higher bacterial diversity saliva compared feces, distinct differences at both phylum genus levels. Feces primarily contained Firmicutes, while dominated Bacteroidetes Proteobacteria. Notably, Escherichia-Shigella Fusobacterium feces Streptococcus showed increasing abundance from average adenoma colorectal cancer. Specific dominant flora identified between including CRC adenomas different stages. Seventeen core shared were identified, networks constructed for each group. Functional analysis highlighted This study’s findings on characteristic samples offer valuable insights distinguishing healthy individuals, patients, those distinguish CRC, offering diagnostic reference.