Cardiac MRI and Echocardiography for Early Diagnosis of Cardiomyopathy Among Boys With Duchenne Muscular Dystrophy: A Cross-Sectional Study

• DOI: 10.3389/fped.2022.818608
• Publication Date: 2022-03-14T07:26:52Z
• Authors: Nidhi Prakash; Renu Suthar; Bhupendra Kumar S...; Uma Debi; Rohit Manoj Kumar; Naveen Sankhyan
• Keywords: Cross-sectional study

Cardiomyopathy is an important cause of morbidity and mortality in boys with Duchenne muscular dystrophy (DMD). Early diagnosis a prerequisite for timely institution cardioprotective therapies.We compared cardiac MRI (CMRI) transthoracic echocardiography (TTE) including tissue Doppler imaging (TDI) speckle tracking (STE) cardiomyopathy early ambulatory DMD.This cross-sectional study was conducted between June 2018 December 2020. Consecutive 7 15 years age DMD were enrolled. Percentage ejection fraction (EF), fractional shortening, wall motion abnormalities, diastolic mitral annulus velocity (Ea), medial ratio (E/Ea), global strain measured STE. CMRI-derived EF, segmental hypokinesia, late gadolinium enhancement (LGE) studied compared.A total 38 The mean 8.8 ± 1.6 years, none had clinical features suggestive dysfunction. In the TTE, EF ≤55% 5 (15%), FS ≤28% 3 (9%), one each left ventricular thinning hypokinesia. TDI, dysfunction, STE showed reduced < 18% (9%) boys. 20 (53%) CMRI presence hypokinesia 9 (24%) LGE 4 (11%) boys.Cardiomyopathy remains clinically asymptomatic among DMD. A significantly higher percentage revealed DMD-related comparison echocardiography.