Giant Pediatric Supratentorial Tumor: Clinical Feature and Surgical Strategy

• DOI: 10.3389/fped.2022.870951
• Publication Date: 2022-05-10T12:26:00Z
• Authors: Zhong-Ding Zhang; Huang-Yi Fang; Chen Pang; Yue Yang; Shi-Ze Li; Ling-Li Zhou; Guang-Hui Bai; Han-Song Sheng
• Keywords: Feature (linguistics)

To analyze the clinical character of giant pediatric supratentorial tumor (GPST) and explore prognostic factors. We analyzed data comprising 35 cases GPST from a single center between January 2015 December 2020. The volume was measured by 3D slicer software based on preoperative magnetic resonance imaging (MRI). Glasgow Outcome Scale (GOS) used to evaluate short-term prognosis. varied 27.3 632.8 ml (mean 129.8 ml/ median 82.8 ml). Postoperative histopathological types include ependymoma, pilocytic astrocytoma, choroid plexus papilloma (CPP), craniopharyngioma, primitive neuroectoderm (PNET), carcinoma (CPC), immature teratoma, atypical teratoid rhabdoid (AT/RT), anaplastic gangliocytoma. Tumors in children younger than 3 years tumors located at hemispheres appeared be larger their respective counterparts, though no statistical significance found. A patient with teratoma died during operation because excessive bleeding. complications cerebrospinal fluid subgaleal collection/effusion, infection, neurological deficits, seizures. mean GOS score patients 6 months is 3.43 ± 1.12, 83% (29/35) showed improvement. Favorable characteristics indicated better included small (≤100 ml) (p = 0.029), low-grade (WHO I-II) 0.001), gross total resection (GTR) 0.015). WHO grade highly correlated (correlation coefficient -0.625, p < 0.001). GTR were also -0.428, 0.010). prognosis type. Smaller are more likely achieve might lead higher score. Early diagnosis important for management.