Presepsin as a promising biomarker for early detection of post-operative infection in children

• DOI: 10.3389/fped.2023.1036993
• Publication Date: 2023-03-13T05:11:20Z
• Authors: Niken Wahyu Puspa...; Mulya Rahma Karyanti; Tiara Nien Paramita; Hikari Ambara Sjakti; Nina Dwi Putri; Bambang Tridjaja; Piprim Basarah Ya...; Kshetra Rinaldhy; Ahmad Yani; Pramita Gayatri
• Keywords: White blood cell; Cut-off

Post-operative systemic inflammation response syndrome (SIRS) is an event that results from surgical trauma, white blood cells contact activation, and intra-surgical bacterial translocation, which difficult to distinguish sepsis. Presepsin a novel biomarker increased since the early stages of infection can be used confirm diagnosis post-operative infectious complications. This study aimed investigate diagnostic performance presepsin for complications compared other well-known biomarkers.This cross-sectional included 100 patients admitted Cipto Mangunkusumo National Hospital Bunda in Jakarta, Indonesia. The objective was identify optimal cutoff trend plasma concentration on first third day after surgery compare them with biomarkers.Plasma level higher group non-infection (median 806.5 pg/ml vs. 717 980 516 day, respectively). levels tended increase + 252 pg/ml) children infection. opposite observed -222.5 pg/ml). delta, three-day difference between had best biomarkers (Area Under Curve 0.825). delta diagnose +90.5 pg/ml.Serial assessments days post-surgery their trends are helpful markers clinicians detect children.