Association between PER and CRY gene polymorphisms and the response to caffeine citrate treatment in infants with apnea of prematurity

• DOI: 10.3389/fped.2024.1414185
• Publication Date: 2024-07-22T04:56:02Z
• Authors: Jiang-Biao Xie; Wei Zhuang; Yao Zhu; Zhi Zheng; Yan-Ru Huang; Si-Min Ma; Xin-Zhu Lin
• Keywords: Apnea of prematurity

Background Circadian rhythms impact metabolism and the therapeutic effects of drugs. The purpose this study was to determine association between PER CRY polymorphisms caffeine citrate treatment response in infants with apnea prematurity. Methods A total 221 preterm gestational age <34 weeks were included (160 group 61 non-response group). propensity score matching method used perform a 1:1 for all premature infants, general characteristics clinical outcomes two groups compared. circadian transcription repressors prematurity analyzed co-dominant, dominant, recessive, over-dominant models, as well analysis alleles. Generalized multifactor dimensionality reduction (GMDR) analyze interaction genes. Results After matching, 45 each groups, there no statistically significant differences ( P > 0.05). Infants had higher incidence moderate severe bronchopulmonary dysplasia (BPD) = 0.043), retinopathy (ROP) 0.035), invasive ventilation 0.027), their duration oxygen use 0.041) longer. When corrected false discovery rate, PER3 rs228669 recessive model FDR 0.045) both associated response. Preterm CC genotype significantly lower rate (OR 0.28, 95% CI 0.12–0.66), which CT 4.18, 1.64–10.66). GMDR revealed an genes < Conclusions may play role citrate, influence effectiveness