Positive Effect of Andrographolide Induced Autophagy on Random-Pattern Skin Flaps Survival

• DOI: 10.3389/fphar.2021.653035
• Publication Date: 2021-03-16T06:34:31Z
• Authors: Jingtao Jiang; Jie Jin; Junsheng Lou; Jiafeng Li; Hongqiang Wu; Sheng Cheng; Chengji Dong; Hongyu Chen; Weiyang Gao
• Keywords: Andrographolide; Skin flap

Random-pattern skin flap replantation is generally used in the reconstruction of surgical tissues and covering a series defects. However, ischemia often occurs at distal parts, which lead to necrosis. Previous studies have shown that andrographolide (Andro) protects against ischemic cardiovascular diseases, but little known about effect Andro on viability. Thus, our study aimed building model random-pattern understand mechanism Andro-induced effects survival. In this study, fifty-four mice were randomly categorized into control, group, Andro+3-methyladenine group. The samples obtained postoperative day 7. Subsequently, tissue underwent evaluations such as changes appearance tissue, intensity blood flow, neovascularization density flap. results revealed enhanced viability random flaps by enhancing angiogenesis, inhibiting apoptosis, reducing oxidative stress. Furthermore, also demonstrated administration caused an elevation autophagy, these remarkable impact reversed 3-methyladenine (3-MA), most common autophagy inhibitor. Together, data proves novel evidence potent modulator capable significantly increasing