Limonin Alleviates Non-alcoholic Fatty Liver Disease by Reducing Lipid Accumulation, Suppressing Inflammation and Oxidative Stress

• DOI: 10.3389/fphar.2021.801730
• Publication Date: 2022-01-03T08:38:34Z
• Authors: Yunjia Li; Menghan Yang; Haiyan Lin; Weixin Yan; Guanghui Deng; Haixin Ye; Hao Shi; Chaofeng Wu; Guoliang Ma; Shu Xu; Qinxiang Tan; Zhuowei Gao; Lei Gao
• Keywords: Limonin; Proinflammatory cytokine

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic and continues to rise in worldwide. Limonin a triterpenoid compound widely found fruits citrus plants with wide range pharmacological effects, including anti-cancer, anti-inflammation, anti-viral, anti-oxidation protection properties. However, potential molecular mechanism limonin on NAFLD zebrafish remains unknown. In this study, larvae were exposed thioacetamide establish an model treated for 72 h simultaneously. The human cell line was stimulated lipid mixture meanwhile incubated 24 h. results showed that significantly reduced accumulation droplets down-regulated levels lipogenic transcription factors FASN SREBP1 NAFLD. suppressed macrophages infiltration relative expression pro-inflammatory IL-6, IL-1β TNF-α secreted by macrophages. Besides, could reversed reduction glutathione reactive oxygen species through up-regulating NRF2/HO-1 signaling pathway liver. conclusion, study revealed has protective effect due its resistance deposition as well antioxidant anti-inflammatory actions.