Clinical application of the fracture risk assessment tool in the general population and its correlation with bone turnover markers

• DOI: 10.3389/fphar.2022.1013483
• Publication Date: 2023-01-10T17:57:40Z
• Authors: Zhi Yang; Shu Xuan; Weihong Li; Wan Hu; Ping Tu; Peng Duan
• Keywords: FRAX; Hip Fracture; Bone remodeling

Objective: To compare the risk of osteoporotic fractures between urban and urban-rural fringe populations in southern China to explore effect bone turnover markers on fracture risk. Methods: Epidemiological investigations were conducted areas June 2018. Residents aged 40 years over who signed informed consent forms included. Physical examination questionnaire collection completed. Bone (BTMs) including osteocalcin (OC) beta cross-linked C-telopeptide type 1 collagen (β-CTX) tested. mineral density (BMD) femoral neck lumbar vertebrae 1-4 measured using dual energy X-ray absorptiometry. Fracture assessment tool (FRAX) values calculated show probability major (PMOF) hip (PHF) next 10 years. Results: A total 1,051 participants included this study, 553 498 areas. The average PMOF PHF 3.4 (2.3-5.4) % .6 (.3-1.5) %, respectively. Compared with that populations, BMD was lower FRAX generally higher, especially for women. various mainly negatively correlated positively β-CTX; meanwhile, only OC. After adjusting sex, elevated β-CTX levels significantly increased high populations. In particular, risks could increase by as much 33 times 19.5 times, respectively, Conclusion: Southern may be at fracture. addition being related BMD, value also correlates some BTMs. Combining BTMs better predict