Understanding the Gut-Kidney Axis in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: An Analysis of Gut Microbiota Composition

• DOI: 10.3389/fphar.2022.783679
• Publication Date: 2022-01-24T06:48:53Z
• Authors: Meilian Yu; Lingzhi Li; Qian Ren; Han Feng; Sibei Tao; Lu Cheng; Liang Ma; Shen-Ju Gou; Ping Fu
• Keywords: Lachnospiraceae

Increasing evidence suggested that gut microbiota played critical roles in developing autoimmune diseases. This study investigated the correlation between and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) with kidney injury. We analyzed fecal samples of 23 AAV patients injury using a 16s RNA microbial profiling approach. The alpha-diversity indexes were significantly lower than healthy controls (Sobs P < 0.001, Shannon Chao 0.001). beta-diversity difference demonstrated significant among injury, lupus nephritis (LN), health (ANOSIM, p = Among these patients, Deltaproteobacteria, unclassified_o_Bacteroidales, Prevotellaceae, Desulfovibrionaceae Paraprevotella, Lachnospiraceae_NK4A136_group correlated negatively serum creatinine, proportion Desulfovibrionaceae, had positive eGFR. In conclusion, richness diversity reduced alteration might be related severity patients. Targeted regulation disorder potential treatment for