Nanoscale Diamond-Based Formulation as an Immunomodulator and Potential Therapeutic for Lymphoma

• DOI: 10.3389/fphar.2022.852065
• Publication Date: 2022-04-04T11:01:43Z
• Authors: Ankush Paladhi; Abhinandan Rej; Debanjan Sarkar; Ranjeet Singh; Sankar Bhattacharyya; Prasanta Kumar Sa...; Pulak Kanti Kar; Partha Pratim Manna; Sumit Kumar Hira
• Keywords: Therapeutic effect

Integrative medicine practices, such as Ayurveda, are popular in India and many South Asian countries, yet basic research to investigate the concepts, procedures, medical benefits of ayurvedic products has received little attention is not fully understood. Here, we report a functional nanodiamond-based traditional Ayurvedic herbomineral formulation, Heerak Bhasma (Ayu_ND), for treatment solid tumors called Dalton's lymphoma generated CD1 mice. Ayu_ND-mediated immunostimulation significantly reduces tumor cell proliferation induces apoptosis aided by active participation dendritic cells. Immunomodulatory Ayu_ND highly immunostimulatory drives cells produce TNF-α. Treatment with volume, inhibits metastasis distant vascularized organs, increases life span tumor-bearing animals compared untreated littermates. These events were associated elevated serum levels protective cytokines IFN-γ TNF-α downregulated disease, exacerbating TGF-β. therapeutic success was also accompanied depletion regulatory T enhanced vaccine-induced T-cell immunity, guided restoration memory CD8+ pool prevention PD-1-mediated exhaustion. The results provide basis further evaluation formulations drug efficacy treating cancers.