Modulation of Tumor Immune Microenvironment and Prognostic Value of Ferroptosis-Related Genes, and Candidate Target Drugs in Glioblastoma Multiforme

• DOI: 10.3389/fphar.2022.898679
• Publication Date: 2022-04-28T04:46:36Z
• Authors: Xudong Zhang; Shengnan Jin; Xin Shi; Shengyu Liu; Kunhang Li; Guojun Liu; Shiyu Zhong; Tao Liu; Lishuai Li; Shanwei Tao; Qingqing Zhai; Nan Bao; Lijie Ren; Ying Wu; Yijun Bao
• Keywords: Pharmacology; 0303 health sciences; Science & Technology; MUTATIONS; SIGNATURE; TEMOZOLOMIDE; BIOLOGY; RM1-950; ferroptosis; 3. Good health; glioblastoma multiforme; 03 medical and health sciences; multi-omics analysis; CELLS; SURVIVAL; IDH1; Pharmacology & Pharmacy; SENSITIZES GLIOBLASTOMA; prognosis; Therapeutics. Pharmacology; 1115 Pharmacology and Pharmaceutical Sciences; Life Sciences & Biomedicine; PACKAGE

Glioblastoma multiforme (GBM) is the most common type of malignant brain tumor, among which IDH1-wild GBM has a poor prognosis. Recent studies have shown that ferroptosis-related genes (FRGs) are correlated with development and progression cancer. In GBM, role FRGs associated IDH1 status as biological indicators therapeutic targets remains to be clarified. Ten (STEAP3, HSPB1, MAP1LC3A, SOCS1, LOX, CAPG, CP, GDF15, CDKN1A, CD44) in were identified key through screening by survival analysis Random Forest using The Cancer Genome Atlas (TCGA) datasets, protein expressions verified. Transwell qPCR results showed ferroptosis promoted migration glioblastoma cells affected expression genes. Our study established prognostic model for patients based on ten different modeling method from previous study, GSVA algorithm. Further, we took methods functional enrichment analysis, clinical characteristics, immune cell infiltration, immunomodulator, ESTIMATE single nucleotide variant (SNV) molecular mechanisms strongly immune-related factors significantly involved p53 signaling pathway, senescence autophagy cancer, negative regulation kinase activity. Moreover, potential drugs Virtual Screening Molecular Docking. indicated novel ferrotosis-related possessed values.