Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels

• DOI: 10.3389/fphar.2022.930832
• Publication Date: 2022-08-11T07:02:31Z
• Authors: Carmen Avagliano; Carmen De Caro; Mariarosaria Cuozzo; Fabrizio Maria Li...; Giovanna La Rana; Laura Micheli; Lorenzo Di Cesare...; Carla Ghelardini; Orlando Paciello; Roberto Russo
• Keywords: Cecum; Dysbiosis

Obesity is a health concern worldwide, and its onset multifactorial. In addition to metabolic syndrome, high-fat diet induces many deleterious downstream effects, such as chronic systemic inflammation, loss of gut barrier integrity, microbial dysbiosis, with reduction butyrate-producing bacteria. These conditions can be ameliorated by increasing legumes in the daily diet. White kidney beans (Phaseolus vulgaris L.) their non-nutritive bioactive component phaseolamin were demonstrated mitigate several pathological features related syndrome-like condition. The aim present study was investigate molecular pathways involved protective effects on intestinal liver environment oral treatment P. extract (PHAS) murine model Results show that PHAS has an anti-inflammatory effect liver, colon, cecum. This mediated peroxisome proliferator-activated receptor (PPAR)-α γ. Moreover, we also observed repeated able restore tight junctions' expression factors colon cecum integrity disrupted HFD mice. improvement correlated significant increase butyrate levels serum fecal samples compared group. data underline prolonged significantly reduces some condition, inflammation disruption; therefore, could valid tool associated therapeutic strategy.