Quercetin Suppresses Human Glioblastoma Migration and Invasion via GSK3β/β-catenin/ZEB1 Signaling Pathway

• DOI: 10.3389/fphar.2022.963614
• Publication Date: 2022-11-01T04:38:10Z
• Authors: Bo Chen; Xiaoli Li; Lihong Wu; Duanfang Zhou; Yi Song; Limei Zhang; Qiuya Wu; Qichen He; Gang Wang; Xu Liu; Hui Hu; Weiying Zhou
• Keywords: Pharmacology; 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; glioblastoma; metastasis; GSK3β/β-catenin/ZEB1 signaling; Therapeutics. Pharmacology; RM1-950; epithelial-like mesenchymal transition; quercetin; 3. Good health

High invasiveness is a biological and clinical characteristic of glioblastoma predicts poor prognosis patients. Quercetin, natural flavonoid compound, exhibits anticancer activity. However, we have limited understanding the possible underlying mechanism quercetin in glioblastoma. In this study, investigated effect human cells. Our results showed that markedly suppressed viability cells vitro vivo, significantly inhibited cell migration invasion. Moreover, reversed EMT-like mesenchymal phenotype reduced expression levels EMT-related markers. Furthermore, found GSK-3β/β-catenin/ZEB1 signaling Taken together, our demonstrate invasion glioma by suppressing GSK3β/β-catenin/ZEB1 signaling. study provides evidence promising therapeutic compound to treat