DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress

• DOI: 10.3389/fphar.2022.987293
• Publication Date: 2023-01-11T04:50:31Z
• Authors: Hui Zhang; Laifa Wang; Yongping Yang; Chuanhai Cai; Xueqin Wang; Ling Deng; Binsheng He; Wenhu Zhou; Yanhui Cui
• Keywords: Malondialdehyde; Stroke

Currently, the recovery of cognitive function has become an essential part stroke rehabilitation. DL-3-n-butylphthalide (NBP) is a neuroprotective reagent and been used in treatment. Clinical studies have confirmed that NBP can achieve better outcomes ischemic patients than healthy controls. In this study, we aimed to investigate influences on reperfusion (I/R) rat model. Our results showed profoundly decreased neurological scores, reduced cerebral infarct areas enhanced blood flow (CBF). potently alleviated poststroke impairment (PSCI) including depression-like behavior learning, memory social cognition impairments, I/R rats. distinctly suppressed activation microglia astrocytes improved neuron viability brain. inhibited expression inflammatory cytokines, interleukin-6 (IL-6), interleukin-1β (IL-1β) tumor necrosis factor-α (TNF-α), by targeting nuclear factor kappa B/inducible nitric oxide synthase (NF-κB/iNOS) pathway oxidative stress factors, reactive oxygen species (ROS) malondialdehyde (MDA), kelch like ECH associated protein 1/nuclear factor-erythroid 2 p45-related (Keap1/Nrf2) The current study revealed treatment ameliorated rats, possibly synergistically suppressing inflammation stress.