Paraben exposure through drugs in the neonatal intensive care unit: a regional cohort study

• DOI: 10.3389/fphar.2023.1200521
• Publication Date: 2023-06-08T06:04:26Z
• Authors: Silvia Iacobelli; Marie Commins; Simon Lorrain; Beatrice Gouyon; Duksha Ramful; Magali Richard; Anthony Grondin; Jean-Bernard Gouyon; Francesco Bonsante
• Keywords: Paraben

Background and objectives: Environmental factors influence the development of very preterm infants (VPIs, born at less than 32 weeks gestation). It is important to identify all potential sources paraben exposure in these vulnerable infants. We aimed quantify via drug administration a cohort VPI cared for neonatal intensive care units (NICUs). Methods: A prospective, observational study was carried out over five-year period regional setting (two NICUs using same computerized order-entry system). The main outcome paraben-containing drugs. secondary outcomes were: time first exposure, daily intake, number exceeding acceptable intake (ADI: 0-10 mg/kg/d), duration cumulative dose. Results: consisted 1,315 VPIs [BW 1129.9 (±360.4) g]. Among them, 85.5% were exposed In 40.4% infants, occurred during second week life. Mean were, respectively, 2.2 (±1.4) mg/kg/d 33.1 (±22.3) days. 80.3 (±84.6) mg/kg. ADI exceeded 3.5% Lower GA associated with higher longer (p < 0.0001). molecules involved sodium iron feredetate, paracetamol, furosemide, bicarbonate + alginate. Conclusion: Commonly used drugs are source parabens, can be easily NICUs. Efforts needed paraben-free alternative formulations