Therapeutic potential and pharmacological significance of extracellular vesicles derived from traditional medicinal plants

• DOI: 10.3389/fphar.2023.1272241
• Publication Date: 2023-12-01T12:21:38Z
• Authors: Peijie Wu; Wenjun Wu; Shu Zhang; Jun Han; Chao Liu; Han Yu; Xiping Chen; Xiaofeng Chen
• Keywords: Nanocarriers; Extracellular Vesicles

Medicinal plants are the primary sources for discovery of novel medicines and basis ethnopharmacological research. While existing studies mainly focus on chemical compounds, there is little research about functions other contents in medicinal plants. Extracellular vesicles (EVs) functionally active, nanoscale, membrane-bound secreted by almost all eukaryotic cells. Intriguingly, plant-derived extracellular (PDEVs) also have been implicated to play an important role therapeutic application. PDEVs were reported physical properties similar mammalian EVs, which rich lipids, proteins, nucleic acids, pharmacologically active compounds. Besides these properties, exhibit unique advantages, especially intrinsic bioactivity, high stability, easy absorption. found be transferred into recipient cells significantly affect their biological process involved many diseases, such as inflammation tumors. could offer morphological compositional characteristics natural nanocarriers innately shuttling bioactive RNA, substances. In addition, effectively encapsulate hydrophobic hydrophilic chemicals, remain stable, cross stringent barriers. Thus, this study focuses pharmacological action mechanisms applications. We systemically deal with facets PDEVs, ranging from isolation composition, functions, biotherapeutic roles. Efforts made elucidate recent advances re-engineering applied effective, non-immunogenic applications meet ever-stringent demands. Considering its not only provide relevant scientific evidence but replenish inherit precious cultural heritage.