Systematic review of melatonin in cerebral ischemia-reperfusion injury: critical role and therapeutic opportunities

• DOI: 10.3389/fphar.2024.1356112
• Publication Date: 2024-02-05T04:28:57Z
• Authors: Chenguang Zhang; Yumei Ma; Yating Zhao; Na Guo; Chen Han; Qian Wu; Changqing Mu; Yue Zhang; Shutong Tan; Jian Zhang; Xu Liu
• Keywords: Excitotoxicity; Stroke; Cerebral edema

Cerebral ischemia-reperfusion (I/R) injury is the predominant causes for poor prognosis of ischemic stroke patients after reperfusion therapy. Currently, potent therapeutic interventions cerebral I/R are still very limited. Melatonin, an endogenous hormone, was found to be valid in preventing a variety organs. However, systematic review covering all neuroprotective effects melatonin has not been reported yet. Thus, we perform comprehensive overview influence on by collecting available literature exploring latent effect as well stroke. In this review, outline extensive scientific studies and summarize beneficial functions melatonin, including reducing infarct volume, decreasing brain edema, improving neurological attenuating blood-brain barrier breakdown, its key protective mechanisms almost every aspect injury, inhibiting oxidative stress, neuroinflammation, apoptosis, excessive autophagy, glutamate excitotoxicity mitochondrial dysfunction. Subsequently, also predictive implications clinical studies. We hope that our can provide most introduction current advancements new insights into personalized diagnosis treatment