Population pharmacokinetic study in children with vascular anomalies: body weight as a key variable in predicting the initial dose and dosing frequency of sirolimus

• DOI: 10.3389/fphar.2024.1457614
• Publication Date: 2024-09-24T04:43:03Z
• Authors: Lin Fan; Hong-Li Guo; Yue-Tao Zhao; Yue Li; Wei-Jun Wang; Jian Huang; Ya-Hui Hu; Ji-Jun Zou; Feng Chen
• Keywords: Sirolimus; Regimen; Trough Concentration

The main challenges faced when using sirolimus in children with vascular anomalies (VAs) still include significant pharmacokinetic (PK) variability, uncertainty the target concentration range, as well inconsistencies initial dosing and frequency. aim of this study is to establish a new population (PPK) model for VAs guide individualized use sirolimus.