Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study

• DOI: 10.3389/fphar.2024.1514293
• Publication Date: 2025-01-03T06:47:21Z
• Authors: Qian Guo; Xinghua Xu; Xiaohui Li; Yang Mao; Shengqiang Li; Yuxin Yao; Xiang Li; Yaxing Li; Jiayue Feng; Yan Shu; Xingli Xu
• Keywords: Mendelian Randomization

Abdominal aortic aneurysm (AAA) is one of the most dangerous types vascular diseases worldwide. Metabolic disturbance affects disease risk and provide underlying therapeutic targets. Previous studies have reported an association between metabolic disorders AAA. However, evidence a causal relationship blood metabolites AAA still lacking at present. Using Mendelian randomization (MR), we assessed 1,400 serum The inverse variance weighted method (IVW), median, MR-Egger regression, simple mode, as well mode methods were used for evaluating causality Pleiotropy heterogeneity tests further conducted. Through strict screening, 17 known metabolites, 7 unknown 5 metabolite ratios related to identified. Among all 24 found negative associations, while exhibited positive associations. top five associated with increased Oleoyl-linoleoyl-glycerol (18:1/18:2) [2], Glycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH)), Glycochenodeoxycholate 3-sulfate, X-21441 X-24328. In contrast, that linked reduced included Uridine pseudouridine ratio, Octadecanedioate, Phosphate oleoyl-linoleoyl-glycerol (18:1 18:2) [2] 1-(1-enyl-palmitoyl)-GPE (p-16:0), 1-stearoyl-GPG (18:0). identified This MR study may novel significant insight screening prevention