Multifunctional PdH-hydride MOFs for synergistic hydrogen and photothermal antibacterial therapy in accelerated wound healing

• DOI: 10.3389/fphar.2025.1587890
• Publication Date: 2025-04-30T05:40:42Z
• Authors: Qing Wang; Daixing Zhang; Yining Qi; Changbao Huang; Dejun Ding; Chuanliang Liu
• Keywords: photothermal therapy; antibacterial therapy; hydride MOFs; hydrogen therapy; wound healing; Therapeutics. Pharmacology; RM1-950

The growing threat of bacterial infections poses a critical challenge to public health, underscoring the urgent need for innovative antibacterial agents and therapeutic strategies. In response, we have developed multifunctional nanoplatform based on palladium-hydride metal-organic frameworks (P(H)ZPAg) synergistic hydrogen photothermal therapy. This integrates palladium hydride (PdH) encapsulated within zeolitic imidazolate framework (ZIF-8), surface modification with polydopamine (PDA), in situ generation silver nanoparticles (Ag NPs) achieve enhanced efficacy. Comprehensive characterization was performed assess release kinetics, performance, silver-mediated bactericidal activity. potential P(H)ZPAg further evaluated vivo using Staphylococcus aureus-infected rat wound model. demonstrated successful combination release, conversion, ion-based mechanisms. vitro assays revealed potent effects against both Escherichia coli aureus. studies showed that treatment significantly healing clearance compared control groups. These findings highlight combining therapy, ion single markedly improve outcomes. study presents promising strategy development nanotherapeutics, offering novel effective approach managing topical promoting healing.