Resistance Training with Co-ingestion of Anti-inflammatory Drugs Attenuates Mitochondrial Function

• DOI: 10.3389/fphys.2017.01074
• Publication Date: 2017-12-19T06:14:53Z
• Authors: Daniele A. Cardinale; Mats Lilja; Mirko Mandić; Thomas Gustafsson; Filip J. Larsen; Tommy R. Lundberg
• Keywords: Endurance Training; Creatine kinase; Crossover study

Aim: The current study aimed to examine the effects of resistance exercise with concomitant consumption high vs. low daily doses non-steroidal anti-inflammatory drugs (NSAIDs) on mitochondrial oxidative phosphorylation in skeletal muscle. As a secondary aim, we compared eccentric overload conventional training. Methods: Twenty participants were randomized either group taking (3 × 400 mg/day) ibuprofen (IBU; 27 ± 5 year; n = 11) or ingesting dose (1 75 acetylsalicylic acid (ASA; 26 4 9) during 8 weeks supervised knee extensor Each subject's legs complete training program using flywheel (FW) device emphasizing overload, traditional weight stack machine (WS). Maximal (CI+IIP) from permeabilized muscle bundles was assessed high-resolution respirometry. Citrate synthase (CS) activity spectrophotometric techniques and protein content western blotting. Results: After training, CI+IIP decreased (P < 0.05) both IBU (23%) ASA (29%) no difference across medical treatments. Although legs, decrease greater (interaction p 0.015) WS (33%, 0.001) FW (19%, 0.078). CS increased (p 0.027) interactions treatment modality. Protein expression ULK1 groups 0.001). increase quadriceps volume not correlated changes (R 0.16). Conclusion: These results suggest that co-ingestion reduces function but increases content. observed affected by higher NSAIDs consumption, suggesting intervention prime mediator phosphorylation. Finally, noted rescued some reduction seen