Progesterone Regulates Glucose Metabolism Through Glucose Transporter 1 to Promote Endometrial Receptivity

• DOI: 10.3389/fphys.2020.543148
• Publication Date: 2020-09-24T06:55:49Z
• Authors: Hongshuo Zhang; Jia Qi; Yufei Wang; Jing Sun; Zhen Li; Linlin Sui; Jianhui Fan; Chao Liu; Yuhong Shang; Li Kong; Ying Kong
• Keywords: Carbohydrate Metabolism; Snf3; GLUT4

Successful embryo implantation requires receptive endometrium, which is conducive to the process of recognition, adhesion, and invasion within a certain period time inseparable from dynamic interaction between 17β-estradiol (E2) progesterone (P4). Proper glucose metabolism critical for profound physiological changes in endometrium entering state. And transporters (GLUTs) are responsible intracellular uptake first step metabolism. Prior literature has reported presence GLUTs endometrium. However, we still do not understand specific mechanisms this process. In study, identified effect P4 on transporter 1 (GLUT1) using vivo animal models determined regulation by cells. We highly suspect that pregnancy failure may be due reduced GLUT1-mediated metabolism, resulting decrease endometrial receptivity caused an inadequate energy supply synthesis substrate. Here, propose possible mechanism explain how affected utilization under abnormal conditions.