Volume Load-Induced Right Ventricular Failure in Rats Is Not Associated With Myocardial Fibrosis

• DOI: 10.3389/fphys.2021.557514
• Publication Date: 2021-02-26T05:36:28Z
• Authors: Quint A. J. Hagdorn; Kondababu Kurakula; Anne-Marie C. Koop; Guido P. L. Bossers; Emmanouil Mavrogi...; Tom van Leusden; Diederik E. van d...; Rudolf A. de Boer; Marie-José T. H. ...; Rolf M. F. Berger
• Keywords: Myocardial fibrosis; Volume overload; Peripheral edema

Right ventricular (RV) function and failure are key determinants of morbidity mortality in various cardiovascular diseases. Myocardial fibrosis is regarded as a contributing factor to heart failure, but its importance RV has been challenged. This study aims assess whether myocardial drives the transition from compensated decompensated volume load-induced dysfunction.Wistar rats were subjected aorto-caval shunt (ACS, n = 23) or sham (control, 15) surgery, sacrificed after 1 month, 3 months, 6 months. Echocardiography, pressure-volume analysis, assessment gene expression cardiac histology performed.At 6/8 ACS-rats (75%) showed clinical signs (pleural effusion, ascites and/or liver edema), whereas at month no had developed yet. Cardiac output increased two- threefold biventricular dilatation occurred, while LV ejection fraction gradually decreased. At end-systolic elastance (Ees) remained unaltered, Ees decreased substantially. In RV, oxidative stress, inflammation, pro-fibrotic signaling (TGFβ1 pSMAD2/3), present any time point.In ACS rat model, long-term load was initially well tolerated induced overt end-stage However, developed. These findings indicate that not involved dysfunction this model.