Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity

• DOI: 10.3389/fphys.2021.587753
• Publication Date: 2021-03-17T05:09:47Z
• Authors: Anne-Sophie Rousseau; Joseph Murdaca; Gwenaëlle Le Menn; Brigitte Sibille; Walter Wahli; Sébastien Le Garf; Giulia Chinetti; Jaap G. Neels; Isabelle Mothe-Sa...
• Keywords: 0301 basic medicine; Skeletal Muscle; Physiology; skeletal muscle.; [SDV]Life Sciences [q-bio]; aging; immunometabolism; physical capacity; regulatory T cells; skeletal muscle; aging; immunometabolism; 610; 500; physical capacity; regulatory T cells; Regulatory T Cells; 03 medical and health sciences; [SDV.TOX]Life Sciences [q-bio]/Toxicology; QP1-981; :Medicine [Science]; skeletal muscle

Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4 + by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate secondary lymphoid organs involved impairment of skeletal muscle (SKM) regeneration mass maintenance. In this study, we showed that a deletion FAO modulator, peroxisome proliferator-activated receptor beta/delta (PPARβ/δ), specifically (KO-T PPARβ/δ), increased number at day 2 following cardiotoxin-induced SKM regeneration. Older KO-T PPARβ/δ mice maintained prevalence lymph nodes similar young mice. Surprisingly, were protected from effects age on lean fat endurance capacity. Our results lead us propose an original potential role cell metabolism aging maintenance body composition